VWA1 and microtia: Basing on: (1) VWA1 mutation caused the most apparent structural changes; (2) VWA1 associated variance had previously been reported in a patient presenting with mandibulofacial dysostosis and microtia (Zhang et al., 2010); (3) vwa1 showed specific expression in the mandible area of zebrafish, we suspected that VWA1, encoding WARP (von Willebrand factor A-domain-related protein 1), was most likely associated with HFM.