In the present study, point mutations in 8 candidate genes shared by all affected individuals: VWA1, SLC35G4, HRC, KLK1, ZBTB45, FBLN2, HECW1 and PGBD3, were identified by WES in this five-generation HFM pedigree. The gene discussed is FBLN2; the disease is craniofacial microsomia.