Most importantly, it is reported that α-synuclein fibrils amplified from the brains (Strohaker et al., 2019) or CSF (Shahnawaz et al., 2020) of PD patients are structurally different than those from MSA, further suggesting that distinct conformational strains of α-synuclein may underlie the different pathology detected in two synucleinopathies. This evidence concerns the gene SNCA and synucleinopathy.