Trehalose, also leads to an AMPK-dependent and mTOR-independent induction of autophagosome biogenesis and has been also shown to exert beneficial effects on cell survival and autophagy-dependent α-synuclein clearance in cellular (Sarkar et al., 2007; Casarejos et al., 2011; Lan et al., 2012) and animal PD models (Sarkar et al., 2014; Tanji et al., 2015; Wu et al., 2015; He et al., 2016). This evidence concerns the gene MTOR and Parkinson disease.