Specifically, in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), α-synuclein mostly accumulates in Lewy bodies (LBs) and Lewy neurites (LNs) in neurons (Spillantini et al., 1997, 1998), whereas in multiple system atrophy (MSA) α-synuclein deposits mostly within the cytoplasm of oligodendrocytes forming glial cytoplasmic inclusions (GCIs) (Wakabayashi et al., 1998a,b; Nakamura et al., 2015). This evidence concerns the gene SNCA and multiple system atrophy.