SNCA and Parkinson disease: Furthermore, KYP-2047, a prolyl oligopeptidase inhibitor, has also been effectively used against α-synuclein aggregation in both cellular and mouse models of PD (Myohanen et al., 2012), whereas porphyrin phthalocyanine tetrasulfonate, an inhibitor of protein aggregation through binding to vesicle-associated α-synuclein, is suggested to modulate α-synuclein misfolding and toxicity (Fonseca-Ornelas et al., 2014).