HSPA8 and Parkinson disease: Furthermore, the protein levels of the two key CMA markers LAMP2A and HSC70, were reported to be decreased in the human substantia nigra and amygdala of PD brains compared to controls (Alvarez-Erviti et al., 2010), while, more recently, decreased protein levels of LAMP2A correlated with increased α-synuclein accumulation were found in PD brain regions harboring α-synuclein pathology (anterior cingulate cortex) and not in other regions that are spared (occipital cortex) (Murphy et al., 2014).