SNCA and multiple system atrophy: α-synuclein is the main component of the proteinaceous inclusions that represent the main histopathological hallmark of synucleinopathies, designated as LBs and LNs in PD and DLB (Spillantini et al., 1997, 1998) and GCIs in MSA (Wakabayashi et al., 1998a,b).