More recently, it was shown that a novel vaccination modality combining an antigen-presenting cell-targeting glucan particle (GP) vaccine delivery system with encapsulated antigen (α-synuclein) plus rapamycin induced both strong anti-α-synuclein antibody titers and neuroprotective T regulatory (Tregs) responses in synucleinopathy models, being more effective than the humoral or cellular immunization alone (Rockenstein et al., 2018). Here, SNCA is linked to synucleinopathy.