Moreover, MEDI1341, a high affinity α-synuclein antibody that crosses the BBB and binds monomeric and aggregated α-synuclein, prevented cell-to-cell transmission of α-synuclein in PFF-treated neuronal cells and is currently tested in a Phase 1 clinical trial for α-synucleinopathies (ClinicalTrials.gov identifier NCT03272165) (Schofield et al., 2019). The gene discussed is SNCA; the disease is synucleinopathy.