SNCA and Parkinson disease: We and others have shown that only the wild-type α-synuclein and not the PD-linked A53T and A30P forms, the phosphorylated or the dopamine-modified α-synuclein, is degraded via the selective process of chaperone-mediated autophagy (CMA) (Cuervo et al., 2004; Martinez-Vicente et al., 2008; Vogiatzi et al., 2008; Mak et al., 2010).