However, the diversity of α-synuclein pathology observed in α-synucleinopathies is attributed to various events, such as the presence of more than one α-synuclein strain, the intracellular milieu, the interaction of α-synuclein with multiple molecular partners, and the propagation of α-synuclein within different brain regions (Peng et al., 2018b; Longhena et al., 2019). This evidence concerns the gene SNCA and synucleinopathy.