SNCA and multiple system atrophy: Moreover, the antibiotic rifampicin has been used as a destabilizer of α-synuclein fibrils (Li et al., 2004) and a reduction in monomeric, oligomeric and pathological pSer129 α-synuclein has been reported in a rifampicin-treated transgenic MSA mouse model (Ubhi et al., 2008).