VEGFC and primary cutaneous T-cell non-Hodgkin lymphoma: Interestingly, in vitro co-culture of malignant CTCL cell lines with skin fibroblasts enhanced the secretion of VEGF-C by the latter, jointly suggesting that the tumor and stromal cells may engage in a cross-talk that promotes synthesis of VEGF-C which, in turn, stimulates lymphangiogenesis (Pedersen et al., 2013).