It was for example shown that S. aureus isolates from CTCL skin lesions express the pore forming toxin, alpha-toxin, and that the malignant T cells in many patients are considerably more resistant to alpha-toxin-induced cell death than non-malignant CD4 and CD8 T cells (Blümel et al., 2019, 2020; Lindahl et al., 2019). Here, CD8A is linked to primary cutaneous T-cell non-Hodgkin lymphoma.