CDKN1A and hepatocellular carcinoma: Cell cycle arrest in the G0/G1 phase and induction of p21WAF1/CIP1 expression was previously observed in neuroblastoma cells upon HDAC8 silencing, while an increase of cells in G2/M phase of the cell cycle was reported in hepatocellular cancer cells treated with PCI (Tian et al., 2016).