The distinctive structure of HDAC8, in comparison to others class I HDAC family members, allowed the development of high specific HDAC8 inhibitor PCI-34051 (hereafter PCI) (Balasubramanian et al., 2008), previously tested in T-cell lymphoma (Balasubramanian et al., 2008) and AML (Qi et al., 2015). The gene discussed is HDAC8; the disease is acute myeloid leukemia.