Epidermal growth factor receptor overexpression has been observed in about 90% of HNSCC specimens, with the exception of human papillomavirus (HPV)-positive tumors, and correlates with poor disease-free and overall survival, metastasis, and resistance to CDDP-based chemotherapy and radiotherapy (Burtness et al., 2013). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.