EGFR and neoplasm: In detail, in our study, we reported several evidences suggesting that VPA can tackle both CDDP and CX resistance through several mechanisms: (1) by specifically targeting CSCs compartment; (2) by decreasing DNA repair mechanisms and concomitantly increasing CDDP concentrations within tumor cells regulating influx and efflux mechanisms; and (3) by reverting EGFR activation and nuclear translocation, thereby impairing the activation of survival pathways and DNA repair mechanisms.