We have recently reported that the HDACi vorinostat was able to inhibit EGFR phosphorylation and nuclear translocation induced by CDDP plus 5FU combination treatment in HNSCC cells, thereby preventing a mechanism of chemo-resistance and potentiating the antitumor effect (Piro et al., 2019). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.