Researchers also found that embryos derived from NK-depleted dams suffer from intrauterine growth restriction (IUGR) (Freitag et al., 2014); CD49a+Eomes+ subset of NK cells promoted fetal development through the secretion of growth-promoting factors in early pregnancies (Fu et al., 2017), these results suggested that dNK cells participated in fetal growth. This evidence concerns the gene ITGA1 and fetal growth restriction.