HAO1 and neoplasm: This approach has stimulated much interest (Fu et al., 2018; Yu et al., 2018; Xie et al., 2019) and the glucose oxidase GOx has attracted attention (Fu et al., 2019; Yang et al., 2019; Gao et al., 2020; Ren et al., 2020) for its role in the oxidation of glucose to gluconic acid, a reaction that can be harnessed to restrict the glucose supply to tumor cells (Jain, 2014; Gao et al., 2020).