Further studies will be needed in order to validate this and other novel targeted modalities including combination therapy of hypoxia and PD-L1 inhibition.PX-478 can suppress tumor growth both in vitro and in vivo (Zhu et al., 2017), and its apoptosis-promoting and growth suppressor activities have been investigated in several different experimental models, including BCa cells (Welsh et al., 2004). The gene discussed is CD274; the disease is neoplasm.