It is well known that within the hypoxic tumor niche, a high level of HIF-driven adaptations is observed in terms of ECM modeling (Gilkes et al., 2014), expression of immune surface markers PD-L1 (Noman et al., 2014), MUC-1 (Chaika et al., 2012), CD73 (Lan et al., 2018) and hypoxia-induced extracellular vesicles (Ren et al., 2019). The gene discussed is CD274; the disease is neoplasm.