Results exhibited the marked increased viral load, viral sensing gene expression (NLRP3, RIG-1, IFN-β) and production of inflammatory cytokines, specifically IL-1β in the monocytes of individuals with past severe dengue when compared to monocytes of individuals with past non-severe dengue advising the influence of initial innate immune responses and inflammasome components NLRP3, IL-1β in disease outcome (Kamaladasa et al., 2019). Here, NLRP3 is linked to dengue disease.