In addition to the role of Syk activation during ADE in DENV infection, downstream to C-type lectin receptor activation of SyK activation play a crucial role in activating inflammasome during fungal pathogens and helminths infection (Gross et al., 2009; Poeck and Ruland, 2010; Ritter et al., 2010). This evidence concerns the gene SYK and acute disseminated encephalomyelitis.