To note, dengue infected patients plasma demonstrated the elevated levels of type I IFN and IL-18 (Mustafa et al., 2001; Gandini et al., 2013) and these cytokines (type I IFN and IL-18) by producing IFN-γ by γδ T display a physiologically phenomenon in fostering an effective anti-DENV Th1 adaptive-immune response and an important determinant of dengue disease severity. The gene discussed is IL18; the disease is dengue disease.