During secondary dengue infection, antibody-dependent enhancement (ADE) has been an anticipated mechanism in explaining dengue hemorrhagic fever (DHF; Guzman and Vazquez, 2010) and studies have observed higher IL-1β level in DHF patients as compared to DF patients (Cui et al., 2016; Kamaladasa et al., 2016). Here, IL1B is linked to dengue disease.