The activity of B. pertussis T3SS was then suggested to dampen the inflammatory responses in infected mice by inhibiting proinflammatory cytokine production and enhancing anti-inflammatory IL-10 production in the lungs early after infection, which correlated with lower antigen-specific IFN-γ, IL-17 and IgG responses later in the infection (Fennelly et al., 2008). Here, IFNG is linked to infection.