OVOL1 and skin cancer: Consistently, NFATc1 was identified to be a master regulator of chromatin remodeling to regulate hybrid E/M phenotypes in skin cancer in vivo; the proportion of hybrid E/M phenotypes was also shown to be increased by GRHL2, OVOL1/2, and ΔNP63α at the expense of complete EMT cells, thus lending further credence to our results indicating a functional equivalence between NFATc1 and previously identified PSFs such as GRHL2, OVOL1/2, ΔNP63α, and NRF2 (7).