NUMB and non-small cell lung carcinoma: In presence of NFATc, cells undergo a delayed or stalled EMT; thus maintaining cells in hybrid E/M phenotypes; knockdown of NFATc in H1975 NSCLC cells drove the progression toward a complete EMT phenotype, reminiscent of observations made for other PSFs – GRHL2, OVOL2, NUMB, and NRF2 (18–23).