The results showed that VP can up-regulate the RNA (Figure 3A) and protein expression (Figures 3B,C) of not only GRP78, the marker for activated ER stress pathway, but also apoptosis-related CHOP and Caspase-12 in ER stress pathway in a time-dependent manner in human cervical carcinoma cells. Here, HSPA5 is linked to cervical carcinoma.