In addition, a study has shown that miR-29a increases growth and invasion in glioblastoma; this program involves not only coactivation of the AKT/PI3K and Wnt pathways through the downregulation of PTEN and EphB3, but also the activation of a newly discovered Sox4/Hic5 invasion pathway (19). This evidence concerns the gene SOX4 and glioblastoma.