CD274 and triple-negative breast carcinoma: Interestingly, a recent clinical phase 3 study (IMpassion130) assessing the efficacy and safety of atezolizumab (anti-PD-L1 antibody) plus nab-paclitaxel (chemotherapy) in patients with unresectable, locally advanced or metastatic triple-negative breast cancer (TNBC) reported a clinically meaningful overall survival benefit with chemoimmunotherapy in patients with PD-L1 immune cell-positive disease (43).