ccRCC is frequently characterized by the von Hippel Lindau (VHL) tumor suppressor gene lose or inactivation, which leads to the overexpression of the hypoxia-inducible factor-2α (HIF2α), vascular endothelial growth factor (VEGF), and their downstream kinases (7–9). This evidence concerns the gene VEGFA and nonpapillary renal cell carcinoma.