In non-pulmonary cancers, the lysyl oxidase family profoundly promotes the dissemination of cancer cells from the primary site as well as the colonization of and outgrowth at distant sites, including the lung, through direct effects on collagen architecture and tissue biomechanics (41, 139–144), and through the recruitment of myeloid cells to the premetastatic niche (68). The gene discussed is LOX; the disease is cancer.