Suppression of MAPK signaling, or by targeting EGFR, MMP9, amphiregulin, FAK, SRC kinases, ROCK or PI3K, as well as by sustaining or inducing p38 and HOXD10 signaling have proven effective at inducing dormancy in breast and pancreatic cancer models (193, 204) and similar approaches may be effective in NSCLC. The gene discussed is PTK2; the disease is non-small cell lung carcinoma.