Bone Morphogenetic Protein 1 (BMP1) and members of the A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS) family, which are differentially expressed in NSCLC tumors, are required to cleave the N- and C-termini of the pro-collagen peptide to enable collagen fibrillogenesis and deposition (45). Here, BMP1 is linked to non-small cell lung carcinoma.