Conversely, MMP14 expressed by NSCLC cancer cells and myeloid cells in the tumor microenvironment digests the heparin-binding EGF-like growth factor (HB-EGF) to generate both soluble and membrane-bound heparin-independent growth factors that can activate EGFR signaling (150, 151). This evidence concerns the gene EGFR and non-small cell lung carcinoma.