Unlike ESCC, mutations of ERBB2, VEGFA, EGFR, KRAS, GATA4, SMAD4, CCNE1, GATA6, FGF3/4/19, GATA4/6, CDKN2A, and ARID1A were more frequently recognized in EAC patients (11). The gene discussed is ARID1A; the disease is esophageal squamous cell carcinoma.