KMT2D and esophageal squamous cell carcinoma: The results showed that mutations of TP53, CCND1, SOX2, TP63, PIK3CA, PTEN, NFE2L2, MLL2, ZNF750, NOTCH1, MLL2, FGFR1, and RB1 were significantly enriched in ESCC (11), which were consistent with previous studies (63–65).