In contrast, Cheon et al. reported that treatment of human colon cancer cells with the SIRT2-specific inhibitor, AK-1, which inactivates the NFκB/CSN2 pathway to induce proteasomal degradation of Snail, upregulated p21 to induce G1 arrest and delayed proliferation (65). Here, SIRT2 is linked to malignant colon neoplasm.