Farooqi et al. presented novel lysine-based thiourea compounds as potent and selective SIRT2 inhibitors that were less hydrophobic and easier to synthesize than TM (44), which potently inhibited tumor growth in an HCT116 xenograft murine model, supporting a role for SIRT2 as a viable therapeutic target for CRC (66) (Figure 1). This evidence concerns the gene SIRT2 and colorectal carcinoma.