Further, Funato et al. demonstrated that SIRT2 deacetylated C-terminal lysine residues of p73 and inactivated its transcriptional activity, and SIRT2 inhibition in glioblastoma cell lines (GB2 or GB16) resulted in p73-mediated transactivation of PUMA and induction of apoptosis (72) (Figure 1). Here, SIRT2 is linked to glioblastoma.