ALK and non-small cell lung carcinoma: Similarly, in patients with treatment-naïve metastatic non-squamous NSCLC without EGFR or ALK mutations, the combination of standard chemotherapy with Pembrolizumab resulted in significantly longer OS (1-year OS rate: 69.2% vs. 49.4%) and PFS (8.8 months vs. 4.9 months) compared with placebo in KEYNOTE-189 trial (11).