MUC16 and metastatic malignant neoplasm in the lymph nodes: The serum HE4 levels were correlated with myometrial invasion and metastasis, which is consisted with the previous studies (28, 30, 31), But, Antonsen et al. also demonstrated that the CA-125 might be useful in the evaluation of histological grade, lymph node metastases, and myometrial invasion (28).