A previous report exhibited that ES gene set signatures including ES exp1, ES exp2, Nanog targets, Oct4 targets, Sox2 targets, NOS targets, NOS TFs, Myc target1, and Myc target2 were overexpressed and gene sets including Suz12 targets, Eed targets, H3K27 bound, and PRC3 targets were underexpressed in ER-negative and high grade 3 breast cancer patients (31). The gene discussed is POU5F1; the disease is breast carcinoma.