It is interesting that the Sp1 binding site cluster (+181/+214, the NM 005180.5 transcription start site was assigned as +1) and IRES2 (−324/−291, the translation initiation site ATG was assigned as +1) are the same sites, suggesting that this region may regulate both the transcription and the translation of Bmi1 in NPC cells (17). Here, SP1 is linked to nasopharyngeal carcinoma.