A trend to a higher rate of pneumonitis was seen with combinations of immune blockade agents (20% vs. 6.5 and 10.7%) (p = 0.101), and a greater number of cases of arthritis was observed with anti-PD-1 blockade agents (11.3%) than with anti-PD-L1 (3.6%) or than with a combination of immune blockade agents (4%) (p = 0.099). The gene discussed is CD274; the disease is arthritic joint disease.