RUNX1 and Down syndrome: Another example is that of a patient (TARGET-10-PAMEEK) with negative TEL-AML1 (corresponds to 79 points), no trisomies in 4, 10, 17, and 18 (corresponds to 100 points), 12.6% of MRD day 29 (corresponds to 57 points), no Down syndrome (corresponds to 0 points), and DNA index = 1 (corresponds to 0 points).