Additionally, miR-139-5p transcription is inhibited by EZH2 through upregulating H3K27me3; thereby, the downregulation of EZH2 and the upregulation of miR-139-5p impede EMT in lymph node metastasis pancreatic cancer (42). Here, EZH2 is linked to metastatic malignant neoplasm in the lymph nodes.