The subgroup analyses by cancer type have found that a higher level of AST/ALT ratio was associated with poor PFS for UTUC (HR 1.59, 95% CI 1.15–2.20, p = 0.005), RCC (HR 1.52, 95% CI 1.26–1.83, p < 0.001), and BCa (HR 1.79, 95% CI 1.18–2.72, p < 0.001) (Figure 3A). Here, GPT is linked to renal cell carcinoma.