The subgroup analyses by cancer type have identified that a higher level of AST/ALT ratio was correlated with inferior CSS for UTUC (HR 2.46, 95% CI 1.93–3.13, p < 0.001), RCC (HR 1.90, 95% CI 1.46–2.47, p < 0.001) and BCa (HR 2.71, 95% CI 1.39–5.31, p < 0.001) (Figure 2B). This evidence concerns the gene GPT and renal pelvis/ureter urothelial carcinoma.