The subgroup analyses by cancer type have identified that a higher level of AST/ALT ratio was correlated with inferior OS for UTUC (HR 1.91, 95% CI 1.57–2.33, p < 0.001), RCC (HR 1.74, 95% CI 1.47–2.07, p < 0.001) and BCa (HR 1.80, 95% CI 1.43–2.27, p < 0.001), but not for PCa (HR 1.47, 95% CI 0.82–2.64, p = 0.195) (Figure 2A). The gene discussed is GPT; the disease is cancer.