We found that those genes were enriched in the chromosome location 19p13.3 (genes: SEMA6B, LRG1, and PLIN5; overlap = 3/25, P = 5.698e-4), in agreement with several existing literatures (33, 34), which further confirmed the module relationship to the AML. This evidence concerns the gene PLIN5 and acute myeloid leukemia.