CD8A and neoplasm: Based on these data we cannot ascertain whether the CD8+ T cells in the MC38-Tnhigh tumors are less exhausted or less activated, especially as the percentage of IFNγ-producing cells was not different upon in vitro PMA/Ionmycin restimulation of tumor-infiltrating lymphocytes from MC38-MOCK and MC38-Tnhigh tumors (Supplementary Figure 5B).