CXCL12/CXCR4 (C-X-C Motif Chemokine Ligand 12/C-X-C Motif chemokine receptor 4) signal transduction is a candidate for participation in inter-tumor interstitial interaction and has various functions, such as the regulation of cell proliferation, invasion, EMT, metastasis, and angiogenesis in multiple types of malignancy (64). Here, CXCR4 is linked to neoplasm.