Moreover, Thomas et al. performed CXCR4 immunohistochemical staining and semiquantitative scoring on the tumor tissue of 73 head and neck adenoid cystic carcinoma (AdCC) patients and found that high CXCR4 expression in AdCC is associated with an increased risk of local recurrence (67). The gene discussed is CXCR4; the disease is adrenocortical carcinoma, hereditary.