Reduced tumor number and size, reduced angiogenesis and proliferation, increased apoptosis in models of non-small cell lung carcinoma α1-null mice (294, 295); overexpression in colorectal cancers and correlation with Myc oncogene; reduced angiogenesis, increased necrosis and low mitotic index in a xenograft model of colorectal cancers (296); reduced angiogenesis in an experimental breast cancer model (297); correlation with a poor patient outcome in melanoma (298, 299); gain of expression in oral squamous cell carcinomas, broncho-alveolar and gastric carcinomas (300–302). This evidence concerns the gene MYC and melanoma.