Decreased tumorigenicity of cancer cells (328) and matrix stiffness (332) in a challenged xenograft model of lung cancer; correlation with tumor progression and postoperative recurrence in non-small cell lung cancer (333); association with a pro-tumorigenic PDGFRβ-positive subset of cancer associated fibroblasts and correlation with a poor clinical outcome in breast cancer (280); correlation with aggressive phenotypes of breast cancer (334); decreased intratumoral interstitial fluid pressure and collagen structure in a challenged mouse tumor model (335). This evidence concerns the gene PDGFRB and lung cancer.