ITSN1 and colorectal carcinoma: Additionally, analysis of data from The Cancer Genome Atlas (TCGA) suggested that higher CUX1 and ITSN1 were correlated with a worse overall survival in CRC (CUX1, χ2 = 4.8, p = 0.028; ITSN1, χ2 = 5.2, p = 0.0225; Figures 6E,F).