In the present analysis of 1,022 patients treated in our institution from 2007 to 2018, we have shown that molecular subtypes (HR and HER2 status), MFI, sites of extrahepatic metastasis (brain, lung, and bone metastasis), liver function tests (total bilirubin, LDH, and GAR) were independent prognostic factors of BCLM patients. This evidence concerns the gene ERBB2 and bone metastasis.