Grade I meningiomas show high mutation rates of some genes (Table 2), including neurofibromin 2 (NF2), the proto-oncogene v-Akt murine thymoma viral oncogene homolog 1 (AKT1), the ubiquitin ligase tumor necrosis factor receptor-associated factor 7 (TRAF7), the oncogene phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), the pluripotency transcription factor Kruppel-like factor 4 (KLF4), and the gene for the catalytic subunit of RNA polymerase II (POLR2A) (9, 10). This evidence concerns the gene PIK3CA and meningioma.