A clinical observation [100] of chronic hepatitis B patients found that 8-oxoGsn in urine could better reflect the degree of liver inflammation and had better predictive value for the degree of inflammatory activity and fibrosis than pathological results and biochemical indicators, such as Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST). This evidence concerns the gene GPT and inflammatory response.