The TREM2-BAC x 5XFAD mice produced less cortical amyloid plaques than 5XFAD mice at 7 months and had similar performance in contextual fear conditioning tests compared to wildtype mice, indicating that TREM2 expression may somehow reduce the Aβ pathology and alleviate cognitive decline in AD [85]. The gene discussed is TREM2; the disease is Mental deterioration.