Furthermore, as additional evidence supporting the role of histone modifications relevant to AMD pathogenesis, Gnana-Prakasam et al. reported significant increases in mRNA expression of HDAC1, HDAC3, HDAC6 in mouse RPE cells associated with excessive iron levels, which may be considered as one of the risk factors for AMD [40]. The gene discussed is HDAC1; the disease is age-related macular degeneration.