TIMP1 and Tako-tsubo cardiomyopathy: Parkkonen et al. observed a large increase in serum TIMP-1 and MMP-2 levels in patients with takotsubo cardiomyopathy (TTC) compared with that in healthy controls, and proposed that the low MMP-8/TIMP-1 molar ratio may reflect increased transient fibrosis and decreased proteolysis [59].