CORIN and hydrops fetalis: In a cross-sectional study, plasma corin levels were lower in HF patients (365 pg/mL [±SD, 259 pg/mL]; P < 0.001) than in healthy controls, and this reduction was closely related to the severity of the disease (P < 0.001 for NYHA class II vs. class IV; P < 0.05 for NYHA class III vs. class IV) [85].