Furthermore, the recovery of the EMT in low EDIL3-secreting cells grown in the CM of high EDIL3-secreting cells, and the loss of this process with subsequent cilengitide treatment added weight to the hypothesis that both extracellular EDIL3 levels and the regulation of EMT by EDIL3 are mediated through an autocrine or paracrine mechanism in cancer cells. This evidence concerns the gene EDIL3 and cancer.