CTLA4 and infection: Tregs restrict infection‐induced inflammation via multiple mechanisms, including contact‐dependent inhibitory cell surface receptors (CTLA‐4 and LAG‐3), secretion of inhibitory cytokines (IL‐10 and TGF‐β) and direct lysis (via granzymes).16, 43 By examining the functionary molecules of CXCR3+ Tregs, higher levels of CTLA‐4 and LAG‐3 were detected.