We further found that BP plus aCD47 could induce repolarization of TAMs to M1-like macrophages, which not only blocks the CD47/SIRPα interaction, promoting phagocytosis, but also potentiates the local cross-presentation of tumour-associated antigens, thus activating tumour-specific T-cell activity and further inducing the abscopal effect for fighting metastatic cancer (Fig. 1). The gene discussed is SIRPA; the disease is neoplasm.