Demonstration of the therapeutic potential of mAbs was performed using cetuximab (anti-EGFR mAb), which successively induces EGFR-specific tumor destruction through receptor blockade, subsequently causing EGFR endocytosis and inhibition of intracellular tyrosine kinase function regulating downstream pro-tumorigenic signals [54, 55]. This evidence concerns the gene EGFR and neoplasm.