Therefore, it looks like that according to the levels of the palmitic acid and of the malonic acid, rather than the malic acid, which is an intermediate of the TCA obtained from the conversion of fumarate by fumarase, the metabolic equilibrium in tissue-caspase-4 positive NSCLC patients is shifted towards a lipidomic profile (Figure 7). Here, CASP4 is linked to non-small cell lung carcinoma.