Moreover, according to Li et al., BRG1 interacts with SMAD3 and AP-1 to upregulate histone demethylase JMJD2B, histone acetyltransferase p300, and ASH2 (a key regulatory subunit of the H3K4 methyltransferase complex), which mediates TGF-β-induced transcription of NOX4 in endothelial cells and stimulates the production of ROS, to promote endothelial-mesenchymal transition and liver fibrosis [94]. Here, SMARCA4 is linked to Hepatic fibrosis.