KAT8 and metabolic dysfunction-associated steatohepatitis: Similarly, Liu et al. reported that BRG1 relied on lysine acetyltransferase 8 (KAT8) to activate the transcription of NOX genes (NOX1, NOX2, and NOX4), to promote intracellular ROS production in a mouse model of nonalcoholic steatohepatitis [93].