This finding is supported by studies (and clinical experience) revealing that women without breast cancer who have BRCA1/2 mutations are more likely to choose RRBM (versus surveillance only) if they have a first- or second-degree relative who died from breast cancer [21], particularly if they have lost a mother or sister at young ages (< 60 and < 50 years, respectively) (D. G. Evans, MD, submitted manuscript). This evidence concerns the gene BRCA1 and breast cancer.