Because patients with severe COVID-19 symptoms have multiorgan failure due to the high expression level of cytokines, some of which regulate the function of the organs directly or indirectly via blood endothelial cells that express ACE2, we hypothesize that IL-6 inhibitors including TCZ could mitigate cytokine storms in COVID-19 patients before multiorgan failure. Here, ACE2 is linked to COVID-19.