Then, we explored the diagnostic value of a high ELF3-AS1 expression for glioma specimens, finding that a high ELF3-AS1 expression in the tumor specimens enabled the discrimination of glioma patients from nontumor brain tissues with an AUC of 0.8073, indicating it as a possible diagnostic biomarker for glioma. This evidence concerns the gene ELF3 and central nervous system cancer.