PTGS2 and migraine disorder: COX-2 is an inducible enzyme, and its expression is closely related to the severity of inflammation [31].A study examining COX-2 gene polymorphisms in patients with migraine showed that the COX-2-765 G + genotype was related to an increased risk of migraine [32].In the model of NTG-induced migraine, COX-2 expression was significantly upregulated, but its expression was downregulated by HJZT, and COX-2 plays a role in the midbrain and TG tissues.