The results of this study confirmed that the expression of ERCC1 in HCT-116/L-OHP cells was abnormally increased, as were the expression of Bcl-2, GST-π, MRP, P-gp, and survivin, indicating that the resistance of colorectal cancer cells to L-OHP is mediated through ERCC1. Here, ERCC1 is linked to colorectal cancer.