Therefore, in this study, we from the perspective that “moxibustion regulates VEGF and inhibits the formation of synovial pannus by affecting the serum levels of MMP-1 and MMP-3, thus alleviating synovial inflammation and articular cartilage destruction in RA patients” observe the effect of moxibustion on the contents of MMP-1, MMP-3, and VEGF and explore the response of moxibustion to synovial inflammation as well as its potential bone protective effect in the treatment of RA. This evidence concerns the gene VEGFA and rheumatoid arthritis.