Our previous basic researches and clinical studies have shown that moxibustion at ST36, BL23, and Ashi points can significantly improve the clinical symptoms of RA patients, and its mechanism may be related to the regulation of cytokines and signal pathways, such as IL-1β, TNF-α, HIF-1α, and NF- kB [22, 23]. This evidence concerns the gene HIF1A and rheumatoid arthritis.