Relevant studies have shown that moxibustion can not only repair the central mechanism of RA inflammatory injury, reduce the release of local inflammatory mediators [12], but also regulate the expression of peripheral cytokines and the signal transduction pathway of peripheral inflammatory cells, such as hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4/nuclear factor-κB [13–15]. Here, HIF1A is linked to rheumatoid arthritis.