MMP14 and glioblastoma: Accordingly, Liu et al. have shown that the suppression of cell growth by minocycline is mediated by acidic vesicular organelles development in the cytoplasm, autophagic cell death, and endoplasmic reticulum stress-induced apoptosis in GBM cells [112,113] However, based on Desjarlais et al.'s study, it has been found that part of the minocycline's effects on autophagy could be exerted through the inhibition of MT1-MMP [114].