Besides, the inhibition of p38 MAPK has also been shown to reduce the secretion of proinflammatory cytokines from microglia and tumor cells, resulting in a decrease of GBM migration [109].What is more, minocycline, as a p38 MAPK inhibitor, appears to counteract the protumor phenotype of microglia and reduce tumor growth in vitro and in vivo by inhibiting downstream microglial MT1-MMP expression in mouse models. This evidence concerns the gene MMP14 and neoplasm.