In leukemia cells, Fares et al. and Song et al. have shown that minocycline exerts cytotoxic effects and, consequently, apoptosis through DNA damage, lysosomal degradation, Bcl-xL deamidation, and mitochondria-mediated and caspase-dependent pathways, indicating a therapeutic potential of minocycline in treating leukemia [14, 71]. Here, BCL2L1 is linked to leukemia.